TARGETED PROGRAMS AT 'HYMN'

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The aging process results in multiple traceable footprints, which can be quantified and used to estimate an organism's age. Examples of such aging biomarkers include epigenetic changes, telomere attrition, and alterations in gene expression and metabolite concentrations. More than a dozen aging clocks use molecular features to predict an organism's age, each of them utilizing different data types and training procedures  

The human gut microbiome, inhabiting the intestinal tract, keeps on fluctuating during different stages of life. Recent studies show that unsolicited perturbations in gut microbiota configuration could have strong impact on several features of host health and Ageing. This recently noticed bi-directional relationship between a healthy gut biome and healthy ageing and vice-versa warrants an early correction of GUT related issues and a flourishing gut health are the cornerstones of good ageing.  

Age alone outranks hyperlipidemia, hypertension, and smoking as a clinical predictor of CVD events and is the strongest determinant of heart disease and stroke in several risk factor algorithms. Subclinical CVD, such as atherosclerosis, is present for years prior to diagnosis. Thus, the prevention and slowing of CVD progression from middle age to old age are of utmost importance in promoting healthy aging.  

Stress acts upon the immune system in the way that is often damaging. Stress and ageing alter  the robustness of the immune response. The special focus is on the psychological stress and the impact that it has at different levels, from the whole system to the individual molecules, resulting in consequences for physical health.  

Biological Sciences and Medical Sciences are united in the belief that optimal nutrition and physical activity make a significant contribution to the overall quality of life at any age. The key research challenge lies in deciding which aspects of improved fitness, nutrition, and diet contribute the most to long-term quality-of-life measures.